MLB
- Total: o7.5 -120 Cardinals vs Giants u7.5 -102
- Money Line: +126 Cardinals vs Giants -148
- Watch: NBC / Oracle Park, San Francisco, CA, September 22, 2025 9:45 PM EDT
- Pitching: McGreevy vs Verlander
Oracle Park hosts a marquee NL clash Monday night as the San Francisco Giants welcome the St. Louis Cardinals, first pitch 9:45 PM EDT on NBC. Veteran ace Justin Verlander gets the ball for San Francisco, while Michael McGreevy starts for St. Louis. The Giants are favored at –148 on the moneyline, with the Cardinals offering +126 underdog value.
Trends set the stage for bettors. St. Louis has been strong head-to-head, going 7-2 straight up in its past nine meetings with the Giants. Meanwhile, totals bettors should note that eight of the last 11 matchups between these teams have finished Over the posted number.
With the total set at 7.5 runs, this game delivers classic intrigue—chalk favorite versus live dog.
Betting Trends |
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|---|---|---|---|---|
| The Cardinals are 7-2 straight up in their past nine games versus the Giants. |  |
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Eight of the Giants’ past 11 matchups with the Cardinals have finished OVER the posted total. | |
-The Padres can clinch a postseason berth with a win tonight 👀
-Chris Sale takes the mound as the Braves go for their 9th straight win
-Justin Verlander looks to continue his impressive SeptemberSome Monday night baseball for you ⚾️ pic.twitter.com/Vh1CzFC3DX
— MLB (@MLB) September 22, 2025
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